Mesothelioma - An Asbestos-Related Disease

Asbestos is a group of minerals that naturally occurs in the form of tufts. These fibers can be converted into thin threads that are resistant to heat, chemicals and electricity are not guide. Generally, asbestos is a silicon based compound with several variants such as amphibole, chrysotile ... etc.

Asbestos can be found in the construction of cement, insulation, roofing, boilers, steam pipes, hot water and a host of other products. In the 1900s, asbestos was associated with a variety of respiratory problems, which collectively were known as asbestosis. Later, in 1950, the link between asbestos and mesothelioma was made. Asbestos is now recognized as one of the most potent carcinogens in the environment. However, even today, asbestos can be found in many products of everyday life (eg, fireproof clothing, caulk, clutch plates, brake pads, etc. ...)

Who are the risk of developing mesothelioma?

Asbestos is especially dangerous for those people who work regularly with it. When asbestos-containing material is disturbed, the fibers are released into the atmosphere, and can be brought to people in that environment. Construction works (eg, restoration of old buildings with asbestos-containing cement), Pipefitting, and other such works may be published asbestos fibers which then can be inhaled workers. Secondary exposure is also known to occur. Asbestos fibers are collected dust on the clothing and hair of workers can be brought to their family members. It is known that exposure to as low as two months was sufficient to result in mesothelioma 30-40 years down the line.

Factors that influence the risk of developing mesothelioma

Several factors determine whether exposure to asbestos will cause mesothelioma cancer in the future:

* dose (how much asbestos inhalation)
* Duration (duration of exposure to asbestos)
* Type of asbestos fiber (for mesothelioma, amphibole fibers are considered more dangerous because they remain longer in the lungs and migrate to the mesothelial layer).
* Individual risk factors such as smoking and existing conditions of the lung

How asbestos causes mesothelioma cancer?

When inhaled, asbestos causes the cells to die cause of lung become scarred. Asbestos fibers are slowly working their way to the alveoli at the end of the mesothelium.

for some time now, scientists could not determine the exact route by which asbestos fibers cause cancer. This is because the alleged asbestos necrotic in nature (ie, kills cells). Dead cells should not multiply and form tumors. It is only recently, in 2010, that a paradox is resolved. Asbestos fibers cause programmed cell necrosis, which releases a molecule known as the High-Mobility Group Box 1 (HMGB 1) protein. HMGB1 starts the inflammatory reaction that results in the production of mutagens and tumor growth factors.

mutagenic damage to DNA cells, including those parts that regulate cell reproduction. Cells begin to multiply uncontrollably forming tumora.Faktori stimulate tumor growth extended time, which resulted in mesothelioma and lung cancer, depending on the location of damage.